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Abstract:Objective To investigate the application value of ultrasonic rock salt aerosol combined with high-frequency chest wall oscillation for sputum clearance in the respiratory rehabilitation of patients with chronic obstructive pulmonary disease (COPD). Methods A total of 122 patients of COPD admitted to Shenzhen Guangming District People’s Hospital from May 2024 to May 2025 were selected and randomly divided into two groups using a random number table method, with 61 cases in each group. Both groups received conventional treatment, while the control group was additionally treated with high-frequency chest wall oscillation for sputum clearance, and the observation group was treated with ultrasonic rock salt aerosol therapy on the basis of the control group. The therapeutic efficacy, degree of dyspnea, quality of life, respiratory function, immune indicators were compared between the two groups. Results After treatment, the total effective rate in the observation group was 93.44%, which was higher than 80.33% in the control group, and the difference between the groups was statistically significant (χ2=4.604,P=0.032). The modified Medical Research Council (mMRC) dyspnea score and St. George’s Respiratory Questionnaire (SGRQ) score decreased in both groups; total airway resistance at 5 Hz (R5) and central airway resistance at 20 Hz (R20) decreased; and levels of immunoglobulin A (IgA), immunoglobulin E (IgE), and immunoglobulin M (IgM) decreased. All the above indicators in the observation group were lower than those in the control group, and the differences between the groups were statistically significant (t=-4.595, -3.855, -2.871, -3.000, -4.096, -4.475, -5.549; all P<0.05). Conclusion On the basis of conventional treatment, ultrasonic rock salt aerosol combined with high-frequency chest wall oscillation for sputum clearance, compared with high-frequency chest wall oscillation alone, can more effectively improve the therapeutic efficacy in patients with COPD, alleviate dyspnea, enhance quality of life and respiratory function, and help optimize immune indicator levels.
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