Objective:To study the efficacy and toxicity of oxaliplatin,5-Fu and CF for advanced colorectal carcinoma.Methods:62 colorecta carcinoma patients were randomized into FOLFOX4 group(n=32)and regimen(n=30).All patients received four course of chemotherapy.The treatments were both repeated every 2 weeks.Results:The overall reponse rate of the group with oxaliplatin was 46.9%(15/32).The main toxicity was neurotoxicity.And the overall response rate of the group without oxalip-latin was 16.7%(5/30).Conclusions:Our results indicated that combined oxaliplatin and 5-Fu with CF regimen was effective for advanced eolorectal cancer.And this regimens was superior to that without oxaliplatin.