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电子期刊 >> 正文 |
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摘要：
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MS4A(membrane-spanning 4-domain family,subfamily A)是编码人类和老鼠20多个不同蛋白质的大基因家族,包括CD20、高亲性IgE受体β亚单位(FcεRIβ)和具有造血细胞特性的横跨膜蛋白-IV(HTm4).人类的CD20被指定为MS4A1、FcεRIβ被指定为MS4A2、HTm4被指定为MS4A3,剩余的基因则分别被指定为MS4A4A等6种;老鼠MS4a基因家庭成员被指定为MS4al等15种[1].每个MS4A蛋白质包含4个假定的跨膜域,这些跨膜域有细胞内的
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作者简介：
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参考文献：
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Liang Y,Tedder TF.Identification of a CD20-,FcεRIβ-,and HTm4related gene family:sixteen new MS4A family members expressed in human and mouse.Genomics,2001,72:119-127. Li H,Ayer LM,Polyak MJ,et al.The CD20 calcium channel is localized to microvilli and constitutively associated with membrane rafts.J Biol Chem,2004,279(19):19893-19901. Deans JP,Li H,Polyak MJ.CD20-mediated apoptosis:signaling through lipid rafts.Immunology,2002,107:176-182. Li H,Ayer LM,lytton J,et al.Store-operated cation entry mediated by CD20 in membrane rafts.J Biol Chem,2003,278:42427-42434. Zhang L,McCloskey MA.Immunoglobulin E receptor-activated calcium conductance in rat mast cells.J Physiol,1995,483:59-66. Donato JL,Ko J,Kutok JL,et al.Human HTm4 is a hematopoietic cell cycle regulator.J Clinic Invest,2002,109:51-58. Gingras MC,Lapillonne H,Margolin JF.CFFM4:a new member of the CD20/ FcεRIβ family.Immunogenetics,2001,53:468-76. Bangur CS,Johnson JC,Switzer A,et al.ldentifieation and characterization of L985P,a CD20 related family member overexpressed in small cell lung carcinoma.Int J Oncol,2004,25:1583-1590. Xu H,Williams MS,Spain LM.Patterns of expression membrane localization,and effects of ectopic expression suggest a function for MS4a4 B,a CD20 homology in Thl T cells.Immunology,2006,107:2400-2408. 0 Louvet C,Chiffoleau E,Heslan M,et al.Identification of a new member of the CD20/ FcεRIβ family overexpression in tolerated allografts.Am J Transplant,2005,5:2143-2153.
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