Abstract:ObjectiveTo observe whether prophylactic antibiotics has influence on the incidence of peritonitis during break\|in period.MethodsWe retrospectively summarized 53 patients who were treated with peritoneal dialysis during a period of two years in our hospital,24 females and 29 males,mean age(63.9±12.83)years.These patients were divided into two groups according to the methods of tube sealing after PD catheter insertions.Group A:used 500ml dialysis solution(Dianeal)to wash abdominal cavity after surgery and perfuse abdominal cavity with 20 mg heparin+200 ml Dianeal.Group B:used the same method in group one to wash abdominal cavity after surgery and perfuse abdominal cavity with 20 mg heparin+1.0 g cefazolin+200 ml Dianeal( if the patients were allergic to cefazolin,40000 U gentamicin could be used instead).The quality,the transparency and some other aspects of the effluents should be observed after each drainage.If there was any suspicious case for peritonitis,an immediate test for the effluent of 4 hours dwell would be performed .At the same time,a bacteria culture should also be done.ResultsSix of 33 patients(18%)in the Group A and one of 20 patients(5%)in the Group B had experienced peritonitis episodes.There was no significant difference between the two groups.ConclusionThere was no significant effect of using antibiotics in peritoneal cavity to prevent peritonitis during break\|in period peritonitis after catheter insertion