中国冶金工业医学杂志

三种非典型抗精神病药物治疗精神分裂症对白细胞影响的对照研究*

作者：侯成业1 梁英2#

单位：1．辽宁省复员军人康宁医院辽宁葫芦岛 125100 2北京大学第六医院北京大学精神卫生研究所

分类号：R 749

出版年,卷(期):页码：2017,34(5):499-501

摘要：

摘要：目的探索单一使用非典型抗精神病药物治疗精神分裂症对白细胞的影响。方法用历史性队列研究的方法评估110例精神分裂症患者单一使用利培酮、阿立哌唑或氯氮平治疗精神分裂症患者对白细胞的影响，并且对这些患者的临床处理和转归进行随访。结果在110例患者中，共有6例患者发生白细胞减少，其中氯氮平组2例呈持续下降，程度严重，经应用升白细胞药物仍不能恢复到正常范围；利培酮组4例呈短暂下降，程度较轻，经应用升白细胞药物能够恢复到正常范围，阿立哌唑组未出现白细胞减少病例。结论应用非典型抗精神病药物治疗精神分裂症会出现白细胞下降，阿立哌唑对白细胞影响不明显，利培酮程度相对较轻，但出现频率并不低于氯氮平，这值得临床医生关注。关键词：利培酮；氯氮平；精神分裂症；白细胞减少

Abstract：ObjectiveTo explore the effect on leukocyte of single use of atypical antipsychotics in the treatment of schizophrenia MethodsThe effect on leukocyte of 110 cases with schizophrenia were valuated using one of risperidone,aripiprazole and clozapine with the method of historical cohort study The clinical treatment and prognosis were followed up ResultsIn 110 patients,there were 6 patients with leukopenia occurring totally,2 cases（52%）in the clozapine group had continued to decline and with a serious degree,leukocyte still could not be restored to the normal range with leukocytosis drug; In risperidone group,4 cases（133%）with drop of leukopenia in a short time and,to a lesser extent,could be restored to normal range with leukocytosis drug and there was no leucopenia case in aripiprazole group ConclusionThe application of atypical antipsychiatric for treatment of mental schizophrenia can appear to decrease of leukocyte,the effects of aripiprazole on leukocyte is not obvious,of risperidone is relatively light but the frequency is not lower than that of clozapine,it is worth of clinicians attentionKey Words:Risperidone；Clozapine；Schizophrenia；Leukopenia

基金项目：

*基金项目:北京高等学校“青年英才计划”(YETP0073)

作者简介：

参考文献：

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