Abstract：ObjectiveTo observe the change of bone density in peri\|menopausal women in different periods and provide theoretical guidance for clinical prevention and treatment of postmenopausal osteoporosis MethodsFifty\|one menopausal women were divided into three groups according to menopause，51 patients（Group A）with an average age of （4256±426）；48 menopause（Group B），menopause time＜1 year，the average age of （4812±459）；postmenopausal 54 cases（Group C），menopause time＞ 1 year，the average age of （5223±433） The bone mineral density（BMD）of the lumbar anteroposterior（2~4）and the left hip（femoral neck），major rotator and Fahrenheit triangle were measured by dual energy X\|ray absorptiometry；While detecting the serum levels of estradiol（E2）and bone metabolic indices including type I carboxy terminal peptide（CTX）and amino acid in the middle before osteocalcin（NMID），type I collagen amino terminal propeptide（PINP） Results（1）Compared with group A and group B，BMD in group C decreased significantly（P＜005）；the BMD of L2~4 and femoral neck in group B was significantly lower than that in group A（P＜005） The BMD of major rotator and Fahrenheit triangle in group B was not significantly lower than that in group A（P＞005）（2）The estrogen levels，bone metabolism index in groups showed that serum E2 values were significantly lower and NMID，CTX，PINP levels was significantly increased in group C than that of group A and group B，（P＜005）；the serum E2 values were significantly lower and the levels of NMID，CTX and PINP were significantly higher in group B than that of group A，and the differences were statistically significant（P＜005） ConclusionWith menopause age increased，osteoporosis increased significantly for peri\|menopausal women，so the prevention work should begin as soon as possibleKey Words:Peri\|menopausal period；Osteoporosis；Bone mineral density；Estrogen；Bone metabolism index