Abstract：Objective To provide guidance for clinical use of antibiotics by analyzing the distribution of pathogenic bacteria and drug resistance of
hospitalized patients in Putian Hanjiang Hospital in 2017. Methods The pathogenic bacteria isolated from 8985 specimens of culture and the results of
drug sensitivity test were analyzed retrospectively in 2017. Results A total of 1161 strains of pathogenic bacteria were isolated and the positive rate of
culture was 12.9% . Among them, 807 Gram- negative bacteria were mainly Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa,
Acinetobacter baumannii and Enterobacter cloacae. Extended-spectrum β -lactamase（ESBLs）from Escherichia coli was found in 48 strains（20.5%）.
There were 32 strains（16.6%）of Klebsiella pneumoniae. Major Gram- negative bacteria, which were resistant to Ceftazidime, Tikassim, Cefuroxime,
Piperacillin, and were resistant to Amikacin, Imipenem, Meropenem. Piperacillin and Tazobactam were most sensitively. Gram- positive bacteria 281
strains, mainly Staphylococcus epidermidis, Staphylococcus aureus, Enterococcus faecalis and Streptococcus pneumoniae. Staphylococcus aureus and
Staphylococcus epidermidis showed high resistance to Penicillin, Erythromycin, Oxacillin, Clindamycin and Compound sulfamycin, and were more
sensitive to Furantoin, Quinuptin / daputin and Minocycline. There was not resistance to Vancomycin for Staphylococcus aureus and Staphylococcus
epidermidis was found. The resistance rate of Streptococcus pneumoniae to Erythromycin, Clindamycin and compound sulfamycin was 100% and no
resistant strains were found to teicoplanin,Vancomycin, Tetracycline, Tetracycline and Quinupustine / Dafopentin. Conclusion It is of great
significance to strengthen the monitoring of drug resistant bacteria for the use of antibiotics.
Key Words：Pathogenic bacteria; Distribution; Drug resistance rate; Antibiotics