Abstract：Objective To eexplore the value of ultrasound in diagnosis benign and malignant thyroid lesions. Methods 92 patients with thyroid nodules admitted to our hospital from January 2018 to June 2019 were selected as the research objects. According to the benign and malignant of the disease, they were divided into 54 cases in the benign group and 38 cases in the malignant group. All of them were underwent thyroid ultrasound examination. The ultrasound characteristics of the two groups were compared and explore the value of diagnosis. Results In the malignant group, the aspect ratio of thyroid nodules ≥1, irregular edges, very hypoechoic nodules, microcalcification, incidence of blurring of borders and grade Ⅲ blood flow signals, blood flow spectrum systolic peak velocity, end-diastolic blood flow velocity values were all higher than that in the benign group, and the difference between the two groups was statistically significant（all P＜0.05）; the sensitivity of ultrasound for benign and malignant thyroid nodules was 89.74% and the specificity was 94.34%. Conclusion Color doppler ultrasound has high application value in detecting benign and malignant thyroid lesions. There are obvious differences between the two ultrasound images. It has a high application value and is worthy of promotion.