中国冶金工业医学杂志

贫血对晚期胃肠道肿瘤患者化疗疗效的影响

作者：丁利芳

分类号：R 735

出版年,卷(期):页码：2021,38(6):629-630

摘要：

摘要：目的分析晚期胃肠道肿瘤患者化疗前后血红蛋白（Hb）的变化以及与化疗疗效的关系。方法回顾性分析我院治疗的75例晚期胃肠道肿瘤患者，按照Hb值水平将其分为化疗前后均无贫血组（组1）、化疗后伴有贫血组（组2）、化疗前后均有贫血组（组3），统计化疗前后Hb值变化情况及其对化疗疗效的影响。结果 3组化疗后Hb值均有所降低，且组2、组3化疗后Hb值与化疗前比较，差异均有统计学意义（均P＜0.05）；化疗4周期后，组1的OR值分别与组2、组3比较明显更高，组间比较差异均有统计学意义（均P＜0.05）。结论化疗可导致患者Hb降低，贫血可降低晚期胃肠道肿瘤患者化疗的疗效。

Abstract：Objective To analyze the changes of hemoglobin（Hb）in patients with advanced gastrointestinal tumors before and after chemotherapy and its relationship with chemotherapy efficacy. Methods 75 cases with gastroenteric cancer were retrospectively analyzed. According to the Hb level, they were divided into Group 1 without anemia before and after chemotherapy, Group 2 with anemia after chemotherapy, and Group 3 with anemia group before and after chemotherapy. The statistics changes of Hb before and after chemotherapy and therapeutic effect were made. Results The Hb values of the three groups were all decrease after chemotherapy. The Hb value of Group 2 and Group 3 after chemotherapy were compared with that before chemotherapy, and the differences were statistically significant（all P＜0.05）; after 4 cycles of chemotherapy, the OR value of Group 1 was significantly higher compared with Group 2 and Group 3 respectively, and the differences between the groups were statistically significant（all P＜0.05）. Conclusion Chemotherapy can reduce the Hb, and anemia can reduce the efficacy of chemotherapy in patients with advanced gastrointestinal tumors.

基金项目：

作者简介：

参考文献：

参考文献

［1］ Ludwig H，Van Belle S，Barrett-Lee P，et al. The European Cancer Anaemia Survey （ECAS）：a large，multinational，prospective survey defining the prevalence，incidence，and treatment of anaemia in cancer patients［J］. Eur J Cancer，2013，40（15）：2293-2306.

［2］ Qiu MZ，Xu RH，Ruan DY，et al. Incidence of anemia，leukocytosis，and thrombocytosis in patients with solid tumors in China［J］. Tumour Boil，2015，31（6）：633-641.

［3］ Blackwell K，Gascón P，Sigounas G，et al. rHuEPO and improved treatment

outcomes：potential modes of action［J］. Oncologist，2014，9（S5）：41-47.

［4］ Vaupel P，Mayer A，Briest S，et al. Oxygenation gain factor：a novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers［J］. Cancer Res，2015，63（22）：7634-7637.

［5］ Semenza GL. HIF-1 and tumor progression：pathophysiology and therapeutics

［J］. Trends Mol Med，2014，8（S4）：S62-67.

［6］ Kim JG，Yi JM，Park SJ，et al. Histone demethylase JMJD2B-mediated cell proliferation regulated by hypoxia and radiation in gastric cancer cell［J］. Biochim Biophys Acta，2016，1819（11-12）：1200-1207.

服务与反馈：

【文章下载】【加入收藏】