Abstract：Objective To investigate the correlation between the levels of serum retinol, lipid-carrying protein 2 and the indexes of bone metabolism in women with menopausal osteoporosis. Methods A total of 106 women with menopausal osteoporosis who were hospitalized in our department from April 2018 to August 2019 were selected as the study subjects, and 100 healthy women were selected as control groups during the same period. In the two groups, the change of bone metabolism indexes including type I collagen crosslinked C end peptide（ICTP）, osteocalcin（OC）and osteoline phosphatase（NBAP）and the levels ofserum retinol, lipid-carrying protein 2 were compared, and their correlation was assessed using Pearson’s test. Results In menopausal osteoporosis group, the level of lipid carrier protein 2 was lower, while serum retinol was higher than that in the control group, the differences were all statistically significant（t＝15.79,19.34,all P＜0.05）; the biochemical indexes of bone metabolism in the peripheral blood of women in the menopausal osteoporosis group were all higher than those in the control group（t＝21.69、26.10、12.09, all P＜0.05）. The linear correlation analysis showed that the level of bone metabolic biochemical indexes were negatively correlated with serum retinol（r＝－0.66, P＜0.05）, while were  positively correlated with lipid-carrying protein 2（r＝0.36, P＜0.05）. Conclusion Menopausal osteoporosis women have significant increasing ofserum retinol and decreasing of lipid carrier protein 2,which are related to bone metabolism,so can be used as an objective indicator of risk assessment of osteoporosis in menopausal women.