Abstract：Objective To evaluate the clinical efficacy of manual chiropractic treatment on spinal derived soft tissue injury. Methods From March 2022 to March 2023, a total of 92 patients with spinal soft tissue injury were selected and randomly divided into a study group and a control group, with 46 patients in each group. The control group patients received routine treatment, while the study group underwent manual chiropractic therapy. Pain score, quality of life score, disease recurrence rate, were compared between the two groups. Results After intervention, the pain scores and quality of life scores in the study group were significantly better than those in the control group, with statistically significant differences （t＝55.829, 37.426, 43.783, 42.640, 27.407, all P＜0.05）. The recurrence rate of the disease in the study group was lower than that in the control group, with a statistically significant difference （χ2＝7.181, P＜0.05）. Conclusion Manual spinal manipulation is beneficial for alleviating pain, improving quality of life, and reducing recurrence rates in patients with spinal-origin soft tissue injuries.