 |
电子期刊 >> 正文 |
|
摘要：
|
|
近年来兴起的重组人粒细胞集落刺激因子(rhG-CSF)动员骨髓干细胞治疗急性心肌梗死试验和临床研究已初显成效[1,2],其为治疗急性脑梗死提供了一种简便易行的新方法.rhG-CSF具有动员骨髓中的造血干细胞和骨髓基质细胞的能力[3],此外,还能促进脑源性神经营养因子(BDNF)的分泌,减轻神经损害.本文通过观察经rhG-CSF干预后的局灶性脑缺血大鼠的神经功能和脑缺血周边区BDNF表达的变化情况,以探讨rhG-CSF干预对糖尿病合并脑缺血后的神经的保护作用及其机制.
|
|
|
|
基金项目：
|
|
|
|
作者简介：
|
|
|
|
参考文献：
|
|
Harada M,Qin Y,Takano H,et al.G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes.Nat Med,2005,11 (3):305-311. Sugano y,Anzai T,Yoshukawa T,et al.Granulocyte colonystimulating factor attenuates early ventricular expression after experimental myocardial infarction.Cardiovasc Res,2005,65 (2):446-456. Kocher AA,Schuster MD,Szabolcs MJ,et al.Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis,reduces remodeling and improves cardiac function[J].NatMed,2001,7 (4):430-436. Chen JL,Li Y,Wang L,et aL Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats[J].Stroke,2001,32(4):1005-1011. Shyu WC,Lin SZ,Yang HI,et al.Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells.Circulation,2004,110:1847 1854. Hiroshi Kawada,Shunya Takizawa,Tomomi Takanashi,et al.Administration of Hematopoietic Cytokines in the Subacute Phase After Cerebral Infarction Is Effective for Functional Recovery Facilitating Proliferation of Intrinsic Neural Stem/Progenitor Cells and Transition of Bone Marrow-Derived Neuronal Cells.Circulation,2006,113:701-710. Schabitz WR,Kollmar R,Schwaninger M,et al.Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia.Stroke,2003,34(3):745 751. 于炳新,吕传真,罗玉敏.rhG-CSF增加脑缺血周边区的nestin表达[J].中国临床神经科学,2003.11(2):152-154. Schabitz W,Sommer C,Zoder W,et al.Intravenous brainde2rived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl 22 expression after temporary focal cerebral ischemia[J].Stroke,2000,31(9),2212-2217.
|
|
服务与反馈：
|
|
【文章下载】【加入收藏】
|
|
|
|
|
 |
|
|
 |
|